Lupus Research Alliance announces 33 studies to be presented at ACR Convergence 2024
The Lupus Research Alliance (LRA), the largest private funder of lupus research worldwide, today announced that a total of 33 studies, funded by the organization or supported by its clinical research affiliate Lupus Therapeutics, will be presented at ACR Convergence 2024. The annual meeting of the American College of Rheumatology takes place November 14-19, at the Walter E. Washington Convention Center in Washington, D.C.
The LRA, which seeks to accelerate the discovery and development of patient-centered treatments and diagnostics, pursues strategies to spur advancements from “bench to bedside.” LRA-supported studies presented at ACR Convergence 2024 represent the full continuum of lupus research, from foundational research exploring new avenues of knowledge, to clinical trials evaluating potential new treatments.
ACR Convergence 2024 is met with pride and excitement by the Lupus Research Alliance and Lupus Therapeutics – pride in seeing the fruits of our funding and other initiatives to accelerate drug discovery and development, and excitement as we stand on the precipice of some important advancements.”
Albert T. Roy, LRA President and CEO
“There are more trials in mid-to-late-stage development than ever before, including dapirolizumab pegol in Phase 3 from UCB/Biogen, a Lupus Therapeutics partner. And we are gratified to witness the volume of CAR T cell therapy approaches in clinical development, having invested in 2014 in early research suggesting this approach as a promising intervention to explore for treating lupus,” Roy added.
Foundational research funded by the LRA
Sixteen studies of LRA-funded research (four oral presentations and 12 posters) will be presented. Several focus on Childhood-Onset Systemic Lupus Erythematosus (cSLE), including: a detailed characterization of the disease; the effects of fatigue on pediatric patients’ mental and physical health; and the discovery of Anti-Mitochondrial Antibodies (AMA), which are linked to higher disease activity.
Other studies include: the development of a precision immunotherapy to target harmful B cells in Antiphospholipid Syndrome (APS) patients; the discovery of innate signaling pathways crucial in causing inflammation in lupus patients; and the epidemiology of strokes in children and adults with lupus.
ORAL PRESENTATIONS
Saturday, Nov. 16
Abstract #0837: Bispecific Autoantigen-T Cell Engagers (BaiTE) to Selectively Target Autoreactive B Cells in Antiphospholipid Syndrome
3:00-3:15 PM, Room 103AB
Sunday, Nov. 17
Abstract #1702: Placental Developmental Defects in a Humanized-TLR8 Mouse Model of Spontaneous Anti-Phospholipid Antibody Induced Pregnancy Loss
3:15-3:30 PM, Room 103AB
Monday, Nov. 18
Xist and XChromosome Inactivation in Female Biased Autoimmunity
9:00-9:30 AM, Room 145AB
Abstract #2625: Brain Injury Markers Correlate with Impaired Executive Function and Disease Activity in Children with Systemic Lupus Erythematosus
3:30-3:45 PM, Room 202AB
POSTERS
Saturday, Nov. 16
Poster Session A, 10:30 AM-12:30 PM, Poster Hall:
Sunday, Nov. 17
Poster Session B, 10:30 AM-12:30 PM, Poster Hall:
Abstract #1273: An Investigation of Traumatic Events and Mental Health in cSLE
Monday, Nov. 18
Poster Session C, 10:30 AM-12:30 PM, Poster Hall:
Abstract #1788: Memory B Cell Activation and Dysregulation in Systemic Lupus Erythematosus
Research Conducted by Lupus Therapeutics and the Lupus Clinical Investigators Network (LuCIN)
Lupus Therapeutics, the clinical affiliate of the Lupus Research Alliance, oversees the Lupus Clinical Investigators Network (LuCIN), consisting of 50+ premier, leading medical research institutions in North America, comprised of 200+ providers with expertise in lupus care and clinical trials. The following studies are based on annual surveys of LuCIN investigators and research teams on promoting equity in lupus clinical trials and identifying trial barriers and solutions.
POSTERS
Saturday, Nov. 16
Abstract 0180: Collaborative Solutions to Lupus Trial Challenges for Underrepresented Participant Recruitment & Engagement: Perspectives from the Lupus Clinical Investigators Network (LuCIN)
Poster Session A, 10:30 AM-12:30 PM, Poster Hall
Sunday, Nov. 17
Abstract #1039: Through the LuCIN Lens: Defining Barriers and Forging Solutions for Lupus Clinical Trials in North America
Poster Session B, 10:30 AM-12:30 PM, Poster Hall
Clinical Research Supported by Lupus Therapeutics and LuCIN
The primary goal of Lupus Therapeutics and LuCIN is to accelerate and enhance the quality of lupus clinical trials through clinical expertise, advisory services, patient engagement and partnership/collaboration with biopharmaceutical companies and research partners. Lupus Therapeutics and LuCIN are involved in nearly 25% of active lupus clinical trials. Fifteen Lupus Therapeutics/LuCIN-supported programs and collaborations are being presented at ACR Convergence 2024:
ORAL PRESENTATIONS
Sunday, Nov. 17
Abstract #1773: Safety and Efficacy of CABA-201, a Fully Human, Autologous 4-1BB Anti-CD19 CAR T Cell Therapy in Patients with Immune-Mediated Necrotizing Myopathy and Systemic Lupus Erythematosus from the RESET-MyositisTM and RESET-SLETM Clinical Trials
3:30-3:45 PM, Room 145AB
Monday, Nov. 18
Abstract #2577: Efficacy and Safety of ABBV-599 (Elsubrutinib and Upadacitinib Combination) and Upadacitinib Monotherapy for the Treatment of Systemic Lupus Erythematosus: Results Through 104 Weeks in a Long-Term Extension Study
1:30-1:45 PM, Room 146AB
Abstract #2580: Safety and Efficacy of Subcutaneous Ianalumab (VAY736) for up to 68 Weeks in Patients with Systemic Lupus Erythematosus: Results from Phase 2 Study
2:15-2:30 PM Room 146AB
Tuesday, Nov. 19
***LATE-BREAKING ABSTRACT***
8:00-9:30 AM, 146AB
POSTERS
Saturday, Nov. 16
Poster Session A, 10:30 AM-12:30 PM, Poster Hall:
Sunday, Nov. 17
Poster Session B, 10:30 AM-12:30 PM, Poster Hall:
Monday, Nov. 18
Poster Session C, 10:30 AM-12:30 PM, Poster Hall:
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