Genetic insights into reproductive health and longevity

Led by researchers from the University of Oxford’s Leverhulme Centre for Demographic Science and the University of Iceland, the review explores how genetic variations can explain differences in reproductive health and longevity.

The study provides the most comprehensive review of male and female genetic discoveries of reproductive traits to date, and provides new insights into how our DNA affects when we have children, the timing of menopause, and even how that is connected to how long we live.

Genes at the heart of reproduction

Using the GWAS Catalog, an online database of Genome Wide Association Studies (GWAS), the researchers identified 159 genetic studies and 37 key genes that are linked to reproductive traits such as age at first childbirth, menopause timing, and hormones such as follicle-stimulating hormone (FSH) and testosterone. These findings suggest that genetic factors play a significant role in broader health outcomes as well as influencing fertility.

One gene in particular, FSHB (follicle-stimulating hormone subunit beta), was found to be associated with eleven different reproductive outcomes. This gene helps regulate when menstruation begins and when menopause occurs, highlighting its role in reproductive health and ageing. The review also revealed connections between these reproductive genes and rare genetic disorders, showcasing how DNA impacts both fertility and overall health.

As more people delay parenthood to later ages, it is important to understand the genetic factors underpinning an individual’s reproductive health and fertility window. Our study brings together research on the genetics of reproduction to reveal common genes across traits and insights beyond fertility that are inherently linked to health, body mass index (BMI) and obesity, hormone sensitive cancers, and even psychiatric and behavioural traits.”

Professor Melinda Mills, Senior Lead Author, Director of the Leverhulme Centre for Demographic Science and Oxford Population Health’s Demographic Science Unit

First author Dr. Stefanía Benónísdóttir, Postdoctoral Researcher at the Leverhulme Centre for Demographic Science and University of Iceland, said ‘By consolidating this research, we offer a clearer picture of how genetic factors shape reproductive health. This is essential for advancing healthcare, especially when it comes to infertility and reproductive ageing.’

Longevity, cancer, obesity risk and reproductive traits

The review explored the connections between reproductive genes and longevity, finding that genes like ESR1 (estrogen receptor 1) are linked to reproductive traits as well as to cancer risk. For example, starting puberty earlier or experiencing later menopause may increase the risk of hormone-sensitive cancers like breast cancer, but these same traits are associated with a longer lifespan. The FTO (fat mass and obesity associated) gene – previously found to have strong associations with BMI, obesity risk and type 2 diabetes – was also linked to multiple different reproductive traits. Understanding these genetic links is critical as more people choose to delay having children, making reproductive health and ageing even more intertwined.

Male fertility

While previous research has focused on female reproductive health, the study reviews what is known about the genetics of male fertility. Genes like DNAH2 are shown to play a role in both testosterone levels and sperm function, making it crucial for male reproductive health.

Co-author Vincent Straub, DPhil student at the Leverhulme Centre for Demographic Science and Oxford Population Health, said ‘Male reproductive health is critical to overall fertility but often under-researched. By exploring the genetics of male infertility, we can uncover new insights and potential treatments for those struggling with reproductive challenges.’

Genetics across generations

The review examined how genetic changes affect future generations. As parents age, they accumulate de novo mutations – new, spontaneous genetic changes that can be passed to their children. These mutations can have significant effects on the health and development of offspring, previously discovered by senior co-author Professor Augustine Kong.

This comprehensive review offers crucial insights into how our genes shape reproductive health, fertility, and longevity, providing a foundation for more personalised healthcare approaches that could improve outcomes for individuals and families across generations.